Wnt signaling in cartilage development and degeneration

被引：94

作者：

Chun, Jang-Soo ^{[1
]}

Oh, Hwanhee ^{[1
]}

Yang, Siyoung ^{[1
]}

Park, Meeyoung ^{[1
]}

机构：

[1] Gwangju Inst Sci & Technol, Dept Life Sci, Cell Dynam Res Ctr, Kwangju, South Korea

来源：

BMB REPORTS | 2008年 / 41卷 / 07期

关键词：

cartilage degeneration; cartilage development; chondrocytes; chondrogenesis; hypertrophic maturation; wnt signaling;

D O I：

10.5483/BMBRep.2008.41.7.485

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The Wnt signaling network, which is composed of Wnt Iigands, receptors, antagonists, and intracellular signaling molecules, has emerged as a powerful regulator of cell fate, proliferation, and function in multicellular organisms. Over the past two decades, the cHtical role of Wnt signaling in embryonic cartilage and bone development has been well estabI ished, and much has been leamt regarding the role of Wnt signaling in chondrogenesis and cartilage development However, relatively little is known about the role of Wnt signaling in adult articular cartilage and degenerative cartilage tissue. This review will briefly summarize recent advances in Wnt regulation of chondrogenesis and hypertrophic maturation of chondrocytes, and review data concerning the role of Wnt signaling in the maintenance and degeneration of articular chondrocytes and cartilage.

引用

页码：485 / 494

页数：10

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