Primary virus envelope cross-reactivity of the broadening neutralizing antibody response during early chronic human immunodeficiency virus type 1 infection

被引：26

作者：

Zhang, PF

Chen, X

Fu, DW

Margolick, JB

Quinnan, GV

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Div Trop Publ Hlth, Bethesda, MD 20814 USA

[2] Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 06期

关键词：

D O I：

10.1128/JVI.73.6.5225-5230.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To test the hypothesis that changing neutralizing antibody responses against human immunodeficiency virus type 1 (HIV-1) during chronic infection were a response to emergence of neutralization escape mutants, we cloned expressed and characterized envelope clones from patients in the Multicenter AIDS Cohort Study (MACS). Pseudotyped HIV-1 envelope clones obtained from differing time points were assessed for sensitivity to neutralization by using sera from different times from the same and different patients. Clones from early and late time points during chronic infection had similar neutralization sensitivity, and neutralizing antibody responses cross-reacted with early, late, and heterologous envelopes. The potential for broadly effective HIV-1 immunization is supported.

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页码：5225 / 5230

页数：6

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