Effect of low molecular weight heparin rectal suppository on experimental ulcerative colitis in mice

被引：40

作者：

Luo, Junyong ^{[1
]}

Cao, Jichao ^{[1
]}

Jiang, Xueliang ^{[2
]}

Cui, Huifei ^{[1
]}

机构：

[1] Shandong Univ, Inst Biochem & Biotechnol Drugs, Jinan 250012, Peoples R China

[2] Chinese PLA Gen Hosp Jinan Mil Command, Dept Gastroenterol, Jinan 2500312, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2010年 / 64卷 / 07期

关键词：

Ulcerative colitis; Rectal suppository; Low molecular weight heparin; INFLAMMATORY-BOWEL-DISEASE; FACTOR XA; UNFRACTIONATED HEPARIN; ALPHA PRODUCTION; STEM-CELL; IN-VITRO; MUSASHI-1; THERAPY; RAT; EFFICACY;

D O I：

10.1016/j.biopha.2010.01.013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The objective of this study was to investigate the effect and possible mechanism of rectally administered low molecular weight heparin (LMWH) on experimental ulcerative colitis. LMWH rectal suppository was prepared and its efficacy was studied by macroscopical and histological scoring systems as well as myeloperoxidase activity. Serum levels, including tumor necrosis factor-alpha (TNF alpha), interleukin-6 (IL-6) and a link factor of blood coagulation and inflammation factor Xa (FXa) were assayed by enzyme-linked immunosorbent assay. The expression of Musashi-1 (as an intestinal stem cell marker) in the colons was assessed by immunohistochemical analysis. The results showed that LMWH rectal suppository significantly decreased serum levels of TNF-alpha, IL-6 as well as FXa, while increased the expression of Musashi-1 in colon compared with acetic acid induced ulcerative colitis model group. All these preliminary results indicate LMWH rectal suppository is promising for treatment of ulcerative colitis. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：441 / 445

页数：5

共 29 条

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Randomized comparison of unfractionated heparin with corticosteroids in severe active inflammatory bowel disease [J].