Review of new lipid formulations of amphotericin B

Introduction. - Amphotericin B (amB) remains the gold standard for treatment of invasive fungal infections. Lipid formulations of amB have been developed in an attempt to improve both efficacy and tolerability (especially renal toxicity): amB lipid complex (ABLC), liposomal amB (AmBisome(R)), amB colloidal dispersion (ABCD) and amB in lipid emulsion (Intralipid(R)). This review analyzes the data available in the literature. Current knowledge and key points. - ABLC, AmBisome and ABCD are effective in various fungal infections, including invasive aspergillosis, systemic candidiasis, cryptococcal meningitis, mucormycosis and fusariosis. These formulations are also effective in persistent febrile neutropenia and in leishmaniosis The three formulations show little renal toxicity and are safer than conventional amB in this respect. Preliminary data are available on amB in Intralipid: infusion-related adverse effects are reduced, but few data are available on efficacy in documented mycoses. Future prospects and projects. - Large-scale comparative clinical trials may clarify issues of relative efficacy in various forms of fungal infections. (C) 2001 Editions scientifiques et medicales Elsevier SAS.