Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

被引：23

作者：

Ge, Jun ^{[1
]}

Jacobson, Gunilla B. ^{[1
]}

Lobovkina, Tatsiana ^{[1
]}

Holmberg, Krister ^{[2
]}

Zare, Richard N. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Chalmers, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 47期

基金：

美国国家科学基金会;

关键词：

IN-VIVO; DELIVERY; RNA; SIRNA; MICROSPHERES; INTERFERENCE; EMULSIONS; MECHANISM;

D O I：

10.1039/c0cc04258g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.

引用

收藏

页码：9034 / 9036

页数：3

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