Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer

被引：118

作者：

Candela, Marco ^{[1
]}

Guidotti, Marco ^{[2
]}

Fabbri, Alessia ^{[3
]}

Brigidi, Patrizia ^{[1
]}

Franceschi, Claudio ^{[1
,4
,5
]}

Fiorentini, Carla ^{[3
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[2] Ist Super Sanita, Dept Vet Publ Hlth & Food Safety, I-00161 Rome, Italy

[3] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy

[4] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[5] Univ Bologna, CIG Interdipartimental Ctr L Galvani, I-40126 Bologna, Italy

来源：

CRITICAL REVIEWS IN MICROBIOLOGY | 2011年 / 37卷 / 01期

关键词：

CYTOLETHAL DISTENDING TOXIN; BACTEROIDES-FRAGILIS ENTEROTOXIN; FACTOR-KAPPA-B; ESCHERICHIA-COLI; GUT MICROBIOTA; BILE-ACIDS; LACTOBACILLUS-CASEI; IMMUNE-RESPONSES; EPITHELIAL-CELLS; CROHNS-DISEASE;

D O I：

10.3109/1040841X.2010.501760

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer. The peculiar metabolism of dietary compounds of the individual microbiota complement, its overall immunostimulation and immunomodulatory activity, and eventually the production of toxins that perturb the regulation of cell growth, define the balance of positive and negative risk factors for colorectal cancer development. Moreover, shaping the composition of the human intestinal microbiota, diet has an indirect impact in determining the balance between health and disease. The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset.</.

引用

页码：1 / 14

页数：14

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