Brushite cements were injected into an aqueous solution during their setting reaction. The presence of brushite cement provoked a decrease of the solution pH. The latter decrease was measured over time depending on the time of injection, the mode of injection, and the solution composition. Our results indicated that brushite cements released some acid during setting. The released amount was in the range of 20%-70% of the initial acidity. The released amount was mostly determined by the interfacial area cement-solution. Solubility calculations could be used to predict qualitatively the effect of the interfacial area cement-solution on the solution pH.