What promise does PCSK9 hold?

被引:4
作者
Kastelein, JJP [1 ]
Fouchier, SW [1 ]
Defesche, JC [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1100 DE Amsterdam, Netherlands
关键词
D O I
10.1016/j.jacc.2005.02.056
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1620 / 1621
页数:2
相关论文
共 17 条
[1]   Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].
Abifadel, M ;
Varret, M ;
Rabès, JP ;
Allard, D ;
Ouguerram, K ;
Devillers, M ;
Cruaud, C ;
Benjannet, S ;
Wickham, L ;
Erlich, D ;
Derré, A ;
Villéger, L ;
Farnier, M ;
Beucler, I ;
Bruckert, E ;
Chambaz, J ;
Chanu, B ;
Lecerf, JM ;
Luc, G ;
Moulin, P ;
Weissenbach, J ;
Prat, A ;
Krempf, M ;
Junien, C ;
Seidah, NG ;
Boileau, C .
NATURE GENETICS, 2003, 34 (02) :154-156
[2]   NARC-1/PCSK9 and its natural mutants -: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol [J].
Benjannet, S ;
Rhainds, D ;
Essalmani, R ;
Mayne, J ;
Wickham, L ;
Jin, WJ ;
Asselin, MC ;
Hamelin, J ;
Varret, M ;
Allard, D ;
Trillard, M ;
Abifadel, M ;
Tebon, A ;
Attie, AD ;
Rader, DJ ;
Boileau, C ;
Brissette, L ;
Chrétien, M ;
Prat, A ;
Seidah, NG .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (47) :48865-48875
[3]   USE OF MUTANT FIBROBLASTS IN ANALYSIS OF REGULATION OF CHOLESTEROL-METABOLISM IN HUMAN CELLS [J].
BROWN, MS ;
BRANNAN, PG ;
BOHMFALK, HA ;
BRUNSCHEDE, GY ;
DANA, SE ;
HELGESON, J ;
GOLDSTEIN, JL .
JOURNAL OF CELLULAR PHYSIOLOGY, 1975, 85 (02) :425-436
[4]   A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis [J].
Chen, SN ;
Ballantyne, CM ;
Gotto, AM ;
Tan, YL ;
Willerson, JT ;
Marian, AJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (10) :1611-1619
[5]   No genetic linkage or molecular evidence for involvement of the PCSK9, ARH or CYP7A1 genes in the Familial Hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL receptor and apoB genes [J].
Damgaard, D ;
Jensen, JM ;
Larsen, ML ;
Soerensen, VR ;
Jensen, HK ;
Gregersen, N ;
Jensen, LG ;
Faergeman, O .
ATHEROSCLEROSIS, 2004, 177 (02) :415-422
[6]   Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia [J].
Dubuc, G ;
Chamberland, A ;
Wassef, H ;
Davignon, J ;
Seidah, NG ;
Bernier, L ;
Prat, A .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (08) :1454-1459
[7]   COMPETITIVE INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE BY ML-236A AND ML-236B FUNGAL METABOLITES, HAVING HYPOCHOLESTEROLEMIC ACTIVITY [J].
ENDO, A ;
KURODA, M ;
TANZAWA, K .
FEBS LETTERS, 1976, 72 (02) :323-326
[8]   FAMILIAL HYPERCHOLESTEROLEMIA - IDENTIFICATION OF A DEFECT IN REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY ASSOCIATED WITH OVERPRODUCTION OF CHOLESTEROL [J].
GOLDSTEIN, JL ;
BROWN, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (10) :2804-2808
[9]  
INNERARITY TL, 1990, J LIPID RES, V31, P1337
[10]   FAMILIAL DEFECTIVE APOLIPOPROTEIN B-100 - LOW-DENSITY LIPOPROTEINS WITH ABNORMAL RECEPTOR-BINDING [J].
INNERARITY, TL ;
WEISGRABER, KH ;
ARNOLD, KS ;
MAHLEY, RW ;
KRAUSS, RM ;
VEGA, GL ;
GRUNDY, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (19) :6919-6923