The Heart Protection Study: High-risk patients benefit from statins, regardless of LDL-C level

被引：14

作者：

Gurm, HS

Hoogwerf, B

机构：

[1] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Endocrinol & Metab, Cleveland, OH 44195 USA

[3] Cleveland Clin Fdn, Sect Prevent Cardiol, Cleveland, OH 44195 USA

[4] Cleveland Clin Fdn, Internal Med Residency Program, Cleveland, OH 44195 USA

来源：

CLEVELAND CLINIC JOURNAL OF MEDICINE | 2003年 / 70卷 / 11期

关键词：

D O I：

10.3949/ccjm.70.11.991

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The landmark Heart Protection Study (Lancet 2002; 360:7-22) found benefit in treating subjects at high risk of a coronary event with simvastatin 40 mg daily, regardless of baseline low-density lipoprotein cholesterol level and in all subgroups, including women and the elderly. The study found no benefit of simvastatin therapy in preventing noncardiac events (eg, dementia, osteoporotic fractures), and no negative effects, such as an increase in cancer, respiratory disease, or suicide.

引用

页码：991 / 997

页数：7

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