A prototype of giant magnetoimpedance-based biosensing system for targeted detection of gastric cancer cells

被引：76

作者：

Chen, Lei ^{[1
]}

Bao, Chen-Chen ^{[1
]}

Yang, Hao ^{[1
]}

Li, Ding ^{[2
]}

Lei, Chong ^{[1
]}

Wang, Tao ^{[1
]}

Hu, Heng-Yao ^{[1
]}

He, Meng ^{[1
]}

Zhou, Yong ^{[1
]}

Cui, Da-Xiang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Inst Micro & Nano Sci & Technol, Minist Educ, Key Lab Thin Film & Microfabricat,Natl Key Lab Na, Shanghai 200240, Peoples R China

[2] PLA, Hosp 261, Ctr Biol Diag & Therapy, Beijing 100094, Peoples R China

来源：

BIOSENSORS & BIOELECTRONICS | 2011年 / 26卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Giant magnetoimpedance; Gastric cancer cell; Targeted detection; Biosensing system; Prototype; SUPERPARAMAGNETIC NANOPARTICLES; SENSITIVE ELEMENT; ANGIOGENESIS; PARTICLES; MRI; SENSOR;

D O I：

10.1016/j.bios.2010.12.034

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A targeted detection of gastric cancer cells is achieved by combining the giant magnetoimpedance (GMI)-based biosensing system and RGD-4C peptide coupled, chitosan covered superparamagnetic iron oxide particles (RGD-Fe3O4@chitosan). The micro-patterned GMI sensor for targeted detection is made of Co-based ribbon and fabricated by micro electromechanical system (MEMS) technology. Functionalized nanoparticles were designed by coating Fe3O4 with chitosan and conjugating with RGD-4C peptides. The targeted cells were trickled down into the detection area of the system. The detection of each sample is carried out in ten-fold manner and average value is taken as the final result. This system can identify the differences between targeted cells and non-targeted cells. It is of considerable interest due to its potential application in the biomedical field of various specific detections. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：3246 / 3253

页数：8

共 28 条

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