Navigating gene expression using microarrays - a technology review

被引：341

作者：

Schulze, A ^{[1
]}

Downward, J ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Signal Transduct Lab, London WC2A 3PX, England

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 08期

关键词：

D O I：

10.1038/35087138

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Parallel quantification of large numbers of messenger RNA transcripts using microarray technology promises to provide detailed insight into cellular processes involved in the regulation of gene expression. This should allow new understanding of signalling networks that operate in the cell and of the molecular basis and classification of disease. But can the technology deliver such far-reaching promises?

引用

页码：E190 / E195

页数：6

共 44 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J].

Alon, U ;

Barkai, N ;

Notterman, DA ;

Gish, K ;

Ybarra, S ;

Mack, D ;

Levine, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6745-6750

[3] Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].

Bittner, M ;

Meitzer, P ;

Chen, Y ;

Jiang, Y ;

Seftor, E ;

Hendrix, M ;

Radmacher, M ;

Simon, R ;

Yakhini, Z ;

Ben-Dor, A ;

Sampas, N ;

Dougherty, E ;

Wang, E ;

Marincola, F ;

Gooden, C ;

Lueders, J ;

Glatfelter, A ;

Pollock, P ;

Carpten, J ;

Gillanders, E ;

Leja, D ;

Dietrich, K ;

Beaudry, C ;

Berens, M ;

Alberts, D ;

Sondak, V ;

Hayward, N ;

Trent, J .

NATURE, 2000, 406 (6795) :536-540

[4]

Brady G, 2000, YEAST, V17, P211, DOI 10.1002/1097-0061(20000930)17:3<211::AID-YEA26>3.0.CO

[5]

2-7

[6] Gene expression data analysis [J].

Brazma, A ;

Vilo, J .

FEBS LETTERS, 2000, 480 (01) :17-24

[7] One-stop shop for microarray data - Is a universal, public DNA-microarray database a realistic goal? [J].

Brazma, A ;

Robinson, A ;

Cameron, G ;

Ashburner, M .

NATURE, 2000, 403 (6771) :699-700

[8] Knowledge-based analysis of microarray gene expression data by using support vector machines [J].

Brown, MPS ;

Grundy, WN ;

Lin, D ;

Cristianini, N ;

Sugnet, CW ;

Furey, TS ;

Ares, M ;

Haussler, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (01) :262-267

[9] Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays [J].

Bustin, SA .

JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2000, 25 (02) :169-193

[10] Expression profiling in the muscular dystrophies: Identification of novel aspects of molecular pathophysiology [J].

Chen, YW ;

Zhao, P ;

Borup, R ;

Hoffman, EP .

JOURNAL OF CELL BIOLOGY, 2000, 151 (06) :1321-1336

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