Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model

被引：231

作者：

Carbó, N

Costelli, P

Baccino, FM

López-Soriano, FJ

Argilés, JM

机构：

[1] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Barcelona, Spain

[2] Univ Turin, Dipartimento Med & Oncol Sperimentale, Sez Patol Gen, Turin, Italy

[3] CNR, Ctr Immunogencia & Oncol Sperimentale, I-10126 Turin, Italy

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 254卷 / 03期

关键词：

cancer; resveratrol; wine; apoptosis; chemotherapeutic potential;

D O I：

10.1006/bbrc.1998.9916

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resveratrol administration to rats inoculated with a fast growing tumour (the Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25%) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G(2)/M cell cycle phase. Interestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which suggests that resveratrol causes apoptosis in the tumour cell population resulting in a decreased cell number. (C) 1999 Academic Press.

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收藏

页码：739 / 743

页数：5

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