Diabetes Mellitus and Risk of Stroke and Its Subtypes Among Japanese The Japan Public Health Center Study

被引：71

作者：

Cui, Renzhe ^{[1
]}

Iso, Hiroyasu ^{[1
]}

Yamagishi, Kazumasa ^{[2
]}

Saito, Isao ^{[3
]}

Kokubo, Yoshihiro ^{[4
]}

Inoue, Manami ^{[5
]}

Tsugane, Shoichiro ^{[5
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Social & Environm Med, Suita, Osaka 5650871, Japan

[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Publ Hlth Med, Ibaraki, Japan

[3] Ehime Univ, Grad Sch Med, Dept Publ Hlth, Matsuyama, Ehime 790, Japan

[4] Natl Cardiovasc Ctr, Dept Prevent Cardiol, Osaka, Japan

[5] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan

来源：

STROKE | 2011年 / 42卷 / 09期

关键词：

diabetes; epidemiology; follow-up study; stroke; ISCHEMIC-STROKE; GLUCOSE; DISEASE;

D O I：

10.1161/STROKEAHA.111.614313

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians. Methods-A survey was conducted of a total of 13 129 men and 22 528 women aged 40 to 69 years at baseline. During the median 12.0-year follow-up, there were 526 incidences of ischemic strokes (259 lacunar infarctions, 91 large-artery occlusive, and 140 embolic infarctions). Results-The risk of ischemic stroke for both sexes was approximately 2 to 4 times higher for diabetic subjects than for those with normal glucose levels. Significant excess risks of lacunar and embolic infarction for both sexes and of large-artery occlusive infarctions for women were also observed in diabetic subjects. Diabetes mellitus was not associated with risk of intraparenchymal or subarachnoid hemorrhage for either sex. Conclusions-Diabetes mellitus is a significant risk factor for ischemic stroke and all subtypes of ischemic stroke for middle-aged Japanese. (Stroke. 2011;42:2611-2614.)

引用

页码：2611 / 2614

页数：4

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