Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy

被引：28

作者：

Combarros, O

Infante, J

Llorca, J

Berciano, J

机构：

[1] Univ Cantabria, Univ Hosp Marques Valdecilla, Serv Neurol, Santander 39008, Spain

[2] Univ Cantabria, Sch Med, Div Prevent Med, E-39005 Santander, Spain

来源：

MOVEMENT DISORDERS | 2003年 / 18卷 / 11期

关键词：

multiple system atrophy; IL-1A; polymorphism;

D O I：

10.1002/mds.10540

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA. (C) 2003 Movement Disorder Society.

引用

页码：1385 / 1386

页数：2

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