Synthesis of ketones from α-oxocarboxylates and aryl bromides by Cu/Pd-catalyzed decarboxylative cross-coupling

被引：284

作者：

Goossen, Lukas J. ^{[1
]}

Rudolphi, Felix ^{[1
]}

Oppel, Christoph ^{[1
]}

Rodriguez, Nuria ^{[1
]}

机构：

[1] TU Kaiserslautern, FB Chem Organ Chem, D-67663 Kaiserslautern, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 16期

关键词：

aryl ketones; copper; cross-coupling; homogeneous catalysis; palladium;

D O I：

10.1002/anie.200705127

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) The power of two metals: A Pd/Cu catalyst system mediates the in situ formation of acyl nucleophiles by decarboxylation of readily accessible and stable salts of α-oxocarboxylic acids and their cross-coupling with aryl or heteroaryl bromides to give ketones. The reaction may be usedin the presence of many functional groups and provides good yields. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3043 / 3045

页数：3

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