Suppressive effect of coffee on lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized rats

被引：11

作者：

He, PM ^{[1
]}

Noda, Y ^{[1
]}

Sugiyama, K ^{[1
]}

机构：

[1] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Shizuoka 4228529, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 08期

关键词：

coffee; caffeine; theobromine; lipopolysaccharide; hepatitis;

D O I：

10.1271/bbb.65.1924

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A coffee extract significantly suppressed lipopolysaccharide (LPS)-induced hepatitis in D-galactosamine-sensitized rats, as assessed by the plasma alanine and aspartate aminotransferase activities, when it was added to the diet (30 g./kg) and fed to rats for 14 days. Its effect was as strong as that of a green tea extract.. The coffee extract suppressed LPS-induced hepatitis when singly force-fed (1.2 g/kg) 1.5 h prior to the injection of the drugs, whereas a decaffeinated coffee extract had no significant effect. The hepatoprotective effect of caffeine was stronger than that of theobromine. These results indicate that coffee can protect animals from LPS-induced hepatitis, and that the effect of coffee might be mainly due to caffeine.

引用

页码：1924 / 1927

页数：4

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