Stereoselective SN2-substitutions using polyfunctional lithium arylcuprates prepared by an exchange iodine-copper

被引：27

作者：

Calaza, MI ^{[1
]}

Yang, XY ^{[1
]}

Soorukram, D ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 04期

关键词：

D O I：

10.1021/ol0362865

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyfunctional mixed lithium arylcuprates of the type (FG-Ar)(PhMe2CCH2)CuLi obtained via iodine- or bromine-copper exchange with (PhMe2CCH2)(2)CuLi react with cyclic 2-iodoallylic acetates with high S(N)2 selectivity. The addition of ZnBr2 changes this selectivity and allows the performance of highly regioselective and enantioselective anti S(N)2' substitutions using open-chain allylic pentafluorobenzoates.

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页码：529 / 531

页数：3

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