Calcimimetic agents for the treatment of hyperparathyroidism

被引：14

作者：

Goodman, WG ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Med Ctr,Sch Med, Dept Med, Div Nephrol, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 05期

关键词：

D O I：

10.1097/00041552-200109000-00005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Calcimimetic agents are small organic molecules that act as allosteric activators of the calcium sensing receptor. They lower the threshold for receptor activation by extracellular calcium ions and, in parathyroid cells, diminish parathyroid hormone secretion. Calcimimetic compounds represent a novel class of therapeutic agents that may provide a way of controlling excess parathyroid hormone secretion in several clinical disorders. Although experience from clinical trials in humans is limited, available data suggest that calcimimetic agents effectively lower plasma parathyroid hormone levels in patients with primary hyperparathyroidism and those with secondary hyperparathyroidism caused by end-stage renal disease. Calcimimetic compounds thus have considerable potential as a new approach to the medical management of several important clinical disorders of bone and mineral metabolism. Curr Opin Nephrol Hypertens 10:575-580. (C), 2001 Lippincott Williams & Wilkins.

引用

页码：575 / 580

页数：6

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