Insulin-like growth factor and interleukin-1β levels and subsequent fetal size in response to chronic Porphyromonas gingivalis exposure in the pregnant rabbit

Objective: The purpose of this study was to describe maternal insulin-like growth factor, interleukin-1 beta, and fetal size in a rabbit model of Porphyromonas gingivalis exposure. Study design: With the use of a previously described model, 8 New Zealand White rabbits were exposed to either P gingivalis or media during pregnancy and killed at term. Kit and placenta weight were compared between groups. Doe serum insulin-like growth factor system protein and interleukin-1 beta levels were compared by analysis of variance for repeated measures; a probability value of <.05 was considered to be significant. Results: No significant differences in kit and placental weights between exposed and unexposed groups were observed. Insulin-like growth factor system proteins increased significantly as pregnancy progressed, but there were no significant differences in insulin-like growth factor system proteins or interleukin-1 beta between exposed and unexposed does. Conclusion: Chronic P gingivalis exposure does not disrupt insulin-like growth factor system proteins or systemic inflammation and does not impair fetal growth in the pregnant rabbit. Gestational age changes in doe insulin-like growth factor system proteins occur, and the timing of exposure to oral pathogens may influence fetal growth. (C) 2005 Mosby, Inc. All rights reserved.