Golgi disassembly in apoptosis: cause or effect?

被引:43
作者
Machamer, CE [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA
关键词
D O I
10.1016/S0962-8924(03)00101-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural proteins and subsequent disassembly of the organelle could simply be the result of the apoptotic process. However, recent studies raise the intriguing possibility that cleavage of Golgi proteins during apoptosis might be required for more than disassembly of the organelle.
引用
收藏
页码:279 / 281
页数:3
相关论文
共 19 条
[1]   GRASP65, a protein involved in the stacking of Golgi cisternae [J].
Barr, FA ;
Puype, M ;
Vandekerckhove, J ;
Warren, G .
CELL, 1997, 91 (02) :253-262
[2]   A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis [J].
Chiu, R ;
Novikov, L ;
Mukherjee, S ;
Shields, D .
JOURNAL OF CELL BIOLOGY, 2002, 159 (04) :637-648
[3]   Organelle-specific initiation of cell death pathways [J].
Ferri, KF ;
Kroemer, G .
NATURE CELL BIOLOGY, 2001, 3 (11) :E255-E263
[4]   The NH2-terminal domain of golgin-160 contains both Golgi and nuclear targeting information [J].
Hicks, SW ;
Machamer, CE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (39) :35833-35839
[5]   INDUCTION OF APOPTOSIS BY THE MOUSE NEDD2 GENE, WHICH ENCODES A PROTEIN SIMILAR TO THE PRODUCT OF THE CAENORHABDITIS-ELEGANS CELL-DEATH GENE CED-3 AND THE MAMMALIAN IL-1-BETA-CONVERTING ENZYME [J].
KUMAR, S ;
KINOSHITA, M ;
NODA, M ;
COPELAND, NG ;
JENKINS, NA .
GENES & DEVELOPMENT, 1994, 8 (14) :1613-1626
[6]   Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis [J].
Lane, JD ;
Lucocq, J ;
Pryde, J ;
Barr, F ;
Woodman, PG ;
Allan, VJ ;
Lowe, M .
JOURNAL OF CELL BIOLOGY, 2002, 156 (03) :495-509
[7]   Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150Glued stops dynein-dependent membrane motility [J].
Lane, JD ;
Vergnolle, MAS ;
Woodman, PG ;
Allan, VJ .
JOURNAL OF CELL BIOLOGY, 2001, 153 (07) :1415-1426
[8]   Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization [J].
Lassus, P ;
Opitz-Araya, X ;
Lazebnik, Y .
SCIENCE, 2002, 297 (5585) :1352-1354
[9]   Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis [J].
Mancini, M ;
Machamer, CE ;
Roy, S ;
Nicholson, DW ;
Thornberry, NA ;
Casciola-Rosen, LA ;
Rosen, A .
JOURNAL OF CELL BIOLOGY, 2000, 149 (03) :603-612
[10]   Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9 [J].
O'Reilly, LA ;
Ekert, P ;
Harvey, N ;
Marsden, V ;
Cullen, L ;
Vaux, DL ;
Hacker, G ;
Magnusson, C ;
Pakusch, M ;
Cecconi, F ;
Kuida, K ;
Strasser, A ;
Huang, DCS ;
Kumar, S .
CELL DEATH AND DIFFERENTIATION, 2002, 9 (08) :832-841