Genetic factors related to mitochondrial function and risk of diabetes mellitus

被引：41

作者：

Cho, Young Min ^{[1
]}

Park, Kyong Soo ^{[1
]}

Lee, Hong Kyu ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110744, South Korea

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2007年 / 77卷

关键词：

mitochondria; mitochondrial DNA; polymorphism; type; 2; diabetes;

D O I：

10.1016/j.diabres.2007.01.052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mitochondria are the intracellular organelles responsible for the generation of ATP by the process of oxidative phosphorylation (OXPHOS) and have their own DNA containing genes for 13 subunits of OXPHOS and 2 rRNAs and 22 tRNAs for their protein synthesis machinery. Since mitochondrial DNA (mtDNA) has limited coding capacity, nuclear genes make a major contribution to mitochondrial architecture, metabolic systems and biogenesis. Nowadays, there is a growing body of evidence that the mitochondrial dysfunction plays a crucial role in the pathogenesis of type 2 diabetes. In this review, we showed that mtDNA copy number in peripheral blood cells is associated with various pathophysiological characteristics of type 2 diabetes such as insulin resistance and insulin secretory defect. In addition, peripheral blood mtDNA copy number is a risk factor for the development of type 2 diabetes. Common polymorphisms in mtDNA and nuclear genes regulating mitochondrial function might be associated with type 2 diabetes. Elucidation of genetic factors regulating mitochondrial function would be of help to understand how mitochondrial dysfunction is linked to the pathogenesis of type 2 diabetes. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：S172 / S177

页数：6

共 36 条

[1] Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity [J].

Baar, K ;

Song, Z ;

Semenkovich, CF ;

Jones, TE ;

Han, DH ;

Nolte, LA ;

Ojuka, EO ;

Chen, M ;

Holloszy, JO .

FASEB JOURNAL, 2003, 17 (12) :1666-1673

[2] Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1 [J].

Baar, K ;

Wende, AR ;

Jones, TE ;

Marison, M ;

Nolte, LA ;

Chen, M ;

Kelly, DP ;

Holloszy, JO .

FASEB JOURNAL, 2002, 16 (14) :1879-1886

[3] Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes [J].

Chinnery, PF ;

Elliott, HR ;

Patel, S ;

Lambert, C ;

Keers, SM ;

Durham, SE ;

McCarthy, MI ;

Hitman, GA ;

Hattersley, AT ;

Walker, M .

LANCET, 2005, 366 (9497) :1650-1651

[4] Association between polymorphisms in the nuclear respiratory factor 1 gene and type 2 diabetes mellitus in the Korean population [J].

Cho, YM ;

Shin, HD ;

Park, BL ;

Kim, JH ;

Park, KS ;

Kim, SY ;

Lee, HK .

DIABETOLOGIA, 2005, 48 (10) :2033-2038

[5] Variations on a theme: Cataloging human DNA sequence variation [J].

Collins, FS ;

Guyer, MS ;

Chakravarti, A .

SCIENCE, 1997, 278 (5343) :1580-1581

[6] Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus [J].

Ek, J ;

Andersen, G ;

Urhammer, SA ;

Gæde, PH ;

Drivsholm, T ;

Borch-Johnsen, K ;

Hansen, T ;

Pedersen, O .

DIABETOLOGIA, 2001, 44 (12) :2220-2226

[7]

EVANS MJ, 1989, J BIOL CHEM, V264, P14361

[8] NRF-1 - A TRANSACTIVATOR OF NUCLEAR-ENCODED RESPIRATORY GENES IN ANIMAL-CELLS [J].

EVANS, MJ ;

SCARPULLA, RC .

GENES & DEVELOPMENT, 1990, 4 (06) :1023-1034

[9] Mitochondrial evolution [J].

Gray, MW ;

Burger, G ;

Lang, BF .

SCIENCE, 1999, 283 (5407) :1476-1481

[10] A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes [J].

Hara, K ;

Tobe, K ;

Okada, T ;

Kadowaki, H ;

Akanuma, Y ;

Ito, C ;

Kimura, S ;

Kadowaki, T .

DIABETOLOGIA, 2002, 45 (05) :740-743

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