Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment

被引：85

作者：

Beatty, Gregory L. ^{[1
]}

Moon, Edmund K. ^{[2
]}

机构：

[1] Univ Penn, Sch Med, Dept Med, Abramson Canc Ctr,Div Hematol Oncol,Perelman Sch, Philadelphia, PA 19104 USA

[2] Univ Penn, Div Pulm Allergy & Crit Care, Philadelphia, PA 19104 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 11期

关键词：

adoptive cell therapy; cancer; chimeric antigen receptor T cells; immune checkpoint molecules; tumor microenvironment; MESOTHELIN;

D O I：

10.4161/21624011.2014.970027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Chimeric antigen receptor (CAR) modified T cells have shown early promise in hematological malignancies. However, in solid malignancies CAR T cells must overcome a distinct immunosuppressive microenvironment which may compromise their capacity

引用

页码：e970027 / 1

页数：3

共 6 条

[1]

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies [J].

Beatty, Gregory L. ;

Haas, Andrew R. ;

Maus, Marcela V. ;

Torigian, Drew A. ;

Soulen, Michael C. ;

Plesa, Gabriela ;

Chew, Anne ;

Zhao, Yangbing ;

Levine, Bruce L. ;

Albelda, Steven M. ;

Kalos, Michael ;

June, Carl H. .

CANCER IMMUNOLOGY RESEARCH, 2014, 2 (02) :112-120

[2]

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains [J].

Carpenito, Carmine ;

Milone, Michael C. ;

Hassan, Raffit ;

Simonet, Jacqueline C. ;

Lakhal, Mehdi ;

Suhoski, Megan M. ;

Varela-Rohena, Angel ;

Haines, Kathleen M. ;

Heitjan, Daniel F. ;

Albelda, Steven M. ;

Carroll, Richard G. ;

Riley, James L. ;

Pastan, Ira ;

June, Carl H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3360-3365

[3]

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors [J].

Moon, Edmund K. ;

Wang, Liang-Chuan ;

Dolfi, Douglas V. ;

Wilson, Caleph B. ;

Ranganathan, Raghuveer ;

Sun, Jing ;

Kapoor, Veena ;

Scholler, John ;

Pure, Ellen ;

Milone, Michael C. ;

June, Carl H. ;

Riley, James L. ;

Wherry, E. John ;

Albelda, Steven M. .

CLINICAL CANCER RESEARCH, 2014, 20 (16) :4262-4273

[4]

Discovery of Mesothelin and Exploiting It as a Target for Immunotherapy [J].

Pastan, Ira ;

Hassan, Raffit .

CANCER RESEARCH, 2014, 74 (11) :2907-2912

[5]

The Basic Principles of Chimeric Antigen Receptor Design [J].

Sadelain, Michel ;

Brentjens, Renier ;

Riviere, Isabelle .

CANCER DISCOVERY, 2013, 3 (04) :388-398

[6]

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor [J].

Zhao, Yangbing ;

Moon, Edmund ;

Carpenito, Carmine ;

Paulos, Chrystal M. ;

Liu, Xiaojun ;

Brennan, Andrea L. ;

Chew, Anne ;

Carroll, Richard G. ;

Scholler, John ;

Levine, Bruce L. ;

Albelda, Steven M. ;

June, Carl H. .

CANCER RESEARCH, 2010, 70 (22) :9053-9061

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