Low frequency of HLA-B27 and scarcity of ankylosing spondylitis in a Zairean Bantu population

被引：10

作者：

Mbayo, K ^{[1
]}

Mbuyi-Muamba, JM ^{[1
]}

Lurhuma, AZ ^{[1
]}

Halle, L ^{[1
]}

Kaplan, C ^{[1
]}

Dequeker, J ^{[1
]}

机构：

[1] Clin Univ, Kinshasa, DEM REP CONGO

来源：

CLINICAL RHEUMATOLOGY | 1998年 / 17卷 / 04期

关键词：

ankylosing spondylitis; HLA-B27; Zaire;

D O I：

10.1007/BF01451011

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Ankylosing spondylitis (AS) is an inflammatory rheumatic disease which is thought to be rarely seen in African Blacks. Its genetic predisposition has been stressed in Caucasians where the HLA-B27 antigen is firmly linked to the disease. In the present study, HLA-B27 antigen was determined in 146 individuals of Bantu root. Only one of these subjects was found to possess HLA-B27 antigen. This study correlates the low frequency of HLA-B27 with the observed scarcity of AS in patients attending a clinic in Kinshasa for osteoarticular diseases.

引用

页码：309 / 310

页数：2

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