New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains

被引：49

作者：

Gravestock, MB

Acton, DG

Betts, MJ

Dennis, M

Hatter, G

McGregor, A

Swain, ML

Wilson, RG

Woods, L

Wookey, A

机构：

[1] AstraZeneca R&D Boston, Infect Discovery, Waltham, MA 02451 USA

[2] AstraZeneca, Canc & Infect Discovery, Macclesfield SK10 4TG, Cheshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 23期

关键词：

D O I：

10.1016/j.bmcl.2003.07.033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：4179 / 4186

页数：8

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