Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase:: Crystal structure of the type IIβ regulatory subunit

被引：118

作者：

Diller, TC

Madhusudan

Xuong, NH

Taylor, SS

机构：

[1] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

来源：

STRUCTURE | 2001年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0969-2126(00)00556-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Cyclic AMP binding domains possess common structural features yet are diversely coupled to different signaling modules. Each cAMP binding domain receives and transmits a cAMP signal; however, the signaling networks differ even within the same family of regulatory proteins as evidenced by the long-standing biochemical and physiological differences between type I and type II regulatory subunits of cAMP-dependent protein kinase.

引用

页码：73 / 82

页数：10

共 50 条

[1] Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice
Adams, MR
Brandon, EP
Chartoff, EH
Idzerda, RL
Dorsa, DM
McKnight, GS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) : 12157 - 12161
[2] Compensatory regulation of RI alpha protein levels in protein kinase A mutant mice
Amieux, PS
Cummings, DE
Motamed, K
Brandon, EP
Wailes, LA
Le, K
Idzerda, RL
McKnight, GS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) : 3993 - 3998
[3] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY
BAILEY, S
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 : 760 - 763
[4] Bönigk W, 1999, J NEUROSCI, V19, P5332
[5] PKA isoforms, neural pathways, and behaviour: making the connection
Brandon, EP
Idzerda, RL
McKnight, GS
[J]. CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) : 397 - 403
[6] FREE R-VALUE - A NOVEL STATISTICAL QUANTITY FOR ASSESSING THE ACCURACY OF CRYSTAL-STRUCTURES
BRUNGER, AT
[J]. NATURE, 1992, 355 (6359) : 472 - 475
[7] Crystallography & NMR system:: A new software suite for macromolecular structure determination
Brunger, AT
Adams, PD
Clore, GM
DeLano, WL
Gros, P
Grosse-Kunstleve, RW
Jiang, JS
Kuszewski, J
Nilges, M
Pannu, NS
Read, RJ
Rice, LM
Simonson, T
Warren, GL
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1998, 54 : 905 - 921
[8] TOM - A FRODO SUBPACKAGE FOR PROTEIN-LIGAND FITTING WITH INTERACTIVE ENERGY MINIMIZATION
CAMBILLAU, C
HORJALES, E
[J]. JOURNAL OF MOLECULAR GRAPHICS, 1987, 5 (04): : 174 - &
[9] CORBIN JD, 1975, J BIOL CHEM, V250, P218
[10] Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A
Cummings, DE
Brandon, EP
Planas, JV
Motamed, K
Idzerda, RL
McKnight, GS
[J]. NATURE, 1996, 382 (6592) : 622 - 626

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