Mechanisms of venous thrombosis and resolution

被引：298

作者：

Wakefield, Thomas W. ^{[1
,2
]}

Myers, Daniel D. ^{[2
,3
]}

Henke, Peter K. ^{[2
]}

机构：

[1] Univ Michigan, Ctr Cardiovasc, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Surg, Sect Vasc Surg, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Unit Lab Anim Med, Ann Arbor, MI 48109 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2008年 / 28卷 / 03期

关键词：

venous thrombosis; inflammation; selectins; plasminogen; fibrosis;

D O I：

10.1161/ATVBAHA.108.162289

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies.

引用

页码：387 / 391

页数：5

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