The value of increased neopterin levels in reducing transfusion-transmitted virus infections: Detection of a donation from a HBsAg positive chronic carrier by screening of neopterin in Turkish blood donors

Neopterin is an early, sensitive and non-specific marker of cellular immunity. In the present study, serum levels of neopterin were measured by ELISA in 2760 volunteer blood donors, all negative by routine screening tests. Neopterin concentrations ranged from 0.001 to 62.1 nmol/l. 141 donors (5.1%) were found to have high (>= 11 nmol/l) neopterin levels, and 57 of them accepted further investigations within about 3 weeks after their donation. Six had clinical symptoms, and 7 were positive for viral markers. Retesting of neopterin revealed that 2 of 57 donors still showed elevated results, who were adenovirus IgM and HBsAg positive donors, respectively. The present detection of a HBsAg positive donor who yielded negative result initially and a patient with adenovirus infection indicates that routine screening of neopterin levels in blood banks may reduce the risk for viral transmission.