Risk of cancer after the diagnosis of Parkinson's disease: A historical cohort study

被引:55
作者
Elbaz, A
Peterson, BJ
Bower, JH
Yang, P
Maraganore, DM
McDonnell, SK
Ahlskog, JE
Rocca, WA
机构
[1] Mayo Clin & Mayo Fdn, Coll Med, Dept Hlth Sci Res, Div Epidemiol, Rochester, MN 55905 USA
[2] Hop La Pitie Salpetriere, INSERM, U708, Paris, France
[3] Mayo Clin & Mayo Fdn, Coll Med, Dept Neurol, Rochester, MN 55905 USA
关键词
Parkinson's disease; cancer; skin cancer; risk factors; etiology; cohort study;
D O I
10.1002/mds.20401
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We investigated the risk of cancer after the diagnosis of Parkinson's disease (PD) through a historical cohort study. We used the medical records-linkage system of the Rochester Epidemiology Project to identify all incident cases of PD in Olmsted County, Minnesota from 1976 through 1995.Patients with PD were matched by age (1 year) and gender to referent subjects from the same population. For 196 patients and 185 referent subjects, we ascertained the incidence of cancer through medical records abstraction between the date of diagnosis (or index date) and death, loss to follow-up, or end of study. The risk of cancer was higher among patients than in referent subjects (relative risk [RR] = 1.64; 95% confidence interval [CI] = 1.15-2.35; P = 0.007). The RR did not change noticeably after adjustment for smoking. The increased risk was significant for nonmelanoma skin cancer (RR = 1.76 95% CI = 1.07-2.89; P = 0.03), but not for other more severe types of cancer; therefore, we cannot exclude the occurrence of a surveillance bias. Among PD patients, there was no relation between the risk of cancer and the cumulative dose of levodopa received or the use of other PD medications. (c) 2005 Movement Disorder Society.
引用
收藏
页码:719 / 725
页数:7
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