A simple one-pot three-component reaction for preparation of secondary amines and amino esters mediated by lithium perchlorate

被引：36

作者：

Saidi, MR ^{[1
]}

Azizi, N ^{[1
]}

Zali-Boinee, H ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON | 2001年 / 57卷 / 31期

关键词：

secondary amines; aminoesters; lithium perchlorate;

D O I：

10.1016/S0040-4020(01)00636-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The one-pot synthesis of several secondary amines and secondary amino esters are reported. Treatment of aldehydes (aliphatic or aromatic) with (trimethylsilyl)alkylamines, in the presence of 5 M lithium perchlorate in diethyl ether gives intermediate imines. Reaction of these intermediate imines with different nucleophiles and functionalized organozinc reagents, BrZnCH2COOR, produce a variety of secondary amines and N-alkyl- or N-arylamino, esters in good yields. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6829 / 6832

页数：4

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