Inflammatory biomarkers and statins

被引：2

作者：

Blanco-Colio, LM ^{[1
]}

Tuñón, J ^{[1
]}

Martín-Ventura, JL ^{[1
]}

Egido, J ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Cardiol, Vasc Res Lab, Madrid 28040, Spain

来源：

DRUGS OF TODAY | 2005年 / 41卷 / 03期

关键词：

D O I：

10.1358/dot.2005.41.3.892522

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The concept of atherosclerosis as an inflammatory disorder has led to the exploration of new pathogeneses of this disease. In this regard, the levels of several inflammatory molecules are frequently increased in subjects at high risk of developing an acute coronary event. With a simple analysis we can characterize the circulating levels of a marker and its therapeutic modulation with various drugs. In this review we have analyzed different inflammatory markers currently used, such as C-reactive protein (CRP), CD40 ligand, adhesion molecules and chemokines, and their possible modulation by therapeutic intervention with 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors. Moreover, in the future, new technologies will allow us to discover new markers, or sets of them, that could indicate the direction to be taken in the prevention and treatment of cardiovascular diseases. (c) 2005 Prous Science. All rights reserved.

引用

页码：171 / 177

页数：7

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