Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

被引:108
作者
Clarke, PR
Zhang, CM
机构
[1] Univ Dundee, Biomed Res Ctr, Ninewells Hosp & Med Sch, Dundee DD1 9SY, Scotland
[2] Beijing Univ, Dept Cell Biol & Genet, Beijing 100871, Peoples R China
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
D O I
10.1016/S0962-8924(01)02071-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ran is an abundant GTPase that is highly conserved in eukaryotic cells and has been implicated in many aspects of nuclear structure and function, especially determining the directionality of nucleocytoplasmic transport during interphase. However, cell-free systems have recently shown that Ran plays distinct roles in mitotic spindle assembly and nuclear envelope (NE) formation in vitro. During spindle assembly, Ran controls the formation of complexes with importins, the same effectors that control nucleocytoplasmic transport. Here,we review these advances and discuss a general model for Ran in the coordination of nuclear processes throughout the cell division cycle via common biochemical mechanisms.
引用
收藏
页码:366 / 371
页数:6
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