The many roles of an RNA editor

被引：195

作者：

Keegan, LP ^{[1
]}

Gallo, A ^{[1
]}

O'Connell, MA ^{[1
]}

机构：

[1] Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 11期

关键词：

D O I：

10.1038/35098584

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.

引用

页码：869 / 878

页数：10

共 121 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] EDITING FOR AN AMPA RECEPTOR SUBUNIT RNA IN PREFRONTAL CORTEX AND STRIATUM IN ALZHEIMERS-DISEASE, HUNTINGTONS-DISEASE AND SCHIZOPHRENIA [J].

AKBARIAN, S ;

SMITH, MA ;

JONES, EG .

BRAIN RESEARCH, 1995, 699 (02) :297-304

[3] APOBEC-1, THE CATALYTIC SUBUNIT OF THE MAMMALIAN APOLIPOPROTEIN-B MESSENGER-RNA EDITING ENZYME, IS A NOVEL RNA-BINDING PROTEIN [J].

ANANT, S ;

MACGINNITIE, AJ ;

DAVIDSON, NO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) :14762-14767

[4]

BACKUS JW, 1994, BBA-GENE STRUCT EXPR, V1217, P65

[5] SYNTHETIC POLYNUCLEOTIDES AND AMINO ACID CODE .5. [J].

BASILIO, C ;

WAHBA, AJ ;

OCHOA, S ;

SPEYER, JF ;

LENGYEL, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (04) :613-&

[6] A DEVELOPMENTALLY REGULATED ACTIVITY THAT UNWINDS RNA DUPLEXES [J].

BASS, BL ;

WEINTRAUB, H .

CELL, 1987, 48 (04) :607-613

[7]

Bass BL, 1997, RNA, V3, P947

[8] BIASED HYPERMUTATION OF VIRAL-RNA GENOMES COULD BE DUE TO UNWINDING MODIFICATION OF DOUBLE-STRANDED-RNA [J].

BASS, BL ;

WEINTRAUB, H ;

CATTANEO, R ;

BILLETER, MA .

CELL, 1989, 56 (03) :331-331

[9] RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia [J].

Beghini, A ;

Ripamonti, CB ;

Peterlongo, P ;

Roversi, G ;

Cairoli, R ;

Morra, E ;

Larizza, L .

HUMAN MOLECULAR GENETICS, 2000, 9 (15) :2297-2304

[10] MAJOR TRANSCRIPT OF THE FRAMESHIFTED COXLL GENE FROM TRYPANOSOME MITOCHONDRIA CONTAINS 4 NUCLEOTIDES THAT ARE NOT ENCODED IN THE DNA [J].

BENNE, R ;

VANDENBURG, J ;

BRAKENHOFF, JPJ ;

SLOOF, P ;

VANBOOM, JH ;

TROMP, MC .

CELL, 1986, 46 (06) :819-826

← 1 2 3 4 5 6 7 8 9 10 →