Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer

被引：52

作者：

Yao, Katharine ^{[1
]}

Rizzo, Paola ^{[2
]}

Rajan, Prabha ^{[2
]}

Albain, Kathy ^{[2
]}

Rychlik, Karen ^{[2
]}

Shah, Sneha ^{[2
]}

Miele, Lucio ^{[3
]}

机构：

[1] NorthShore Univ Hlth Syst, Evanston Hosp, Evanston, IL 60201 USA

[2] Loyola Univ, Med Ctr, Maywood, IL 60153 USA

[3] Univ Mississippi, Inst Canc, Jackson, MS 39216 USA

来源：

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2011年 / 19卷 / 05期

关键词：

breast cancer; Notch receptors; breast prognostic markers; JAG1 Notch ligand; Notch-1; Notch-4; MAMMARY-TUMORS; IDENTIFICATION; ONCOGENESIS; ACTIVATION; ESTROGEN; POOR; JAG1; RNA;

D O I：

10.1177/1066896910362080

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

Background: Studies looking at immunohistochemical (IHC) staining of Notch receptors in breast cancer and correlation with known prognostic factors are sparse. Methods: IHC staining for nuclear, cytoplasmic, and membrane Notch-1 (N1), Notch-4 (N4), and Jagged-1 (JAG1) was performed and correlated with known prognostic factors. Results: Of 48 breast cancers, 36 (67%) were invasive, mean age was 50 years (range 43-86 years), 37 (77%) were estrogen receptor (ER alpha) positive, and 13 (27%) node positive. There was significantly more marked N1 membranous staining in ER alpha-positive tumors (P < .05). On univariate analysis, cytoplasmic N1 was significantly correlated with node status and tumor grade (P < .05); both cytoplasmic and membranous N4 significantly correlated with Ki67 (P < .05); and membranous JAG1 significantly correlated with Ki67 (P < .05). On multivariate analysis, only cytoplasmic N1 significantly correlated with node status. Conclusion: IHC of Notch markers is feasible and correlates with known prognostic factors consistent with a biological role of Notch signaling in breast cancer progression.

引用

页码：607 / 613

页数：7

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