Time to include the gut microbiota in the hygienic standardisation of laboratory rodents

被引：64

作者：

Bleich, Andre ^{[2
]}

Hansen, Axel Kornerup ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Life Sci, Dept Vet Dis Biol, Sect Biomed, DK-1870 Frederiksberg C, Denmark

[2] Hannover Med Sch, Inst Lab Anim Sci, D-30625 Hannover, Germany

来源：

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES | 2012年 / 35卷 / 02期

关键词：

Gut microbiota; Laboratory rodents; Health monitoring; Animal models; SEGMENTED FILAMENTOUS BACTERIA; INFLAMMATORY-BOWEL-DISEASE; SULFATE-INDUCED COLITIS; MURINE FECAL MICROFLORA; HLA-B27 TRANSGENIC RATS; ALTERED SCHAEDLER FLORA; SODIUM-INDUCED COLITIS; GERM-FREE MICE; LACTOBACILLUS-CASEI; INTESTINAL FLORA;

D O I：

10.1016/j.cimid.2011.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gut microbiota (GM) composition and its impact on animal experiments has become currently dramatically relevant in our days: (1) recent progress in metagenomic technologies, (2) the availability of large scale quantitative analyses to characterize even subtle phenotypes, (3) the limited diversity of laboratory rodent GM due to strict barriers at laboratory animal vendors, and (4) the availability of up to 300.000 different transgenic mouse strains from different sources displaying a huge variety in their GM composition. In this review the GM is described as a variable in animal experiments which need to be reduced for scientific as well as ethical reasons, and strategies how to implement this in routine diagnostic procedures are proposed. We conclude that we have both enough information available to state that the GM has an essential impact on animal models, as well as the methods available to start dealing with these impacts. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：81 / 92

页数：12

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