Decoding Tat:: the biology of HIV Tat posttranslational modifications

被引：46

作者：

Hetzer, C

Dormeyer, W

Schnölzer, M

Ott, M

机构：

[1] Deutsch Krebsforschungszentrum, D-69120 Heidelberg, Germany

[2] Gladstone Inst Virol & Immunol, San Francisco, CA 95158 USA

[3] Univ Calif San Francisco, Dept Med, Sch Med, San Francisco, CA 94143 USA

来源：

MICROBES AND INFECTION | 2005年 / 7卷 / 13期

关键词：

HIV; Tat; posttranslational modification;

D O I：

10.1016/j.micinf.2005.06.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Tat protein is a viral transactivator that activates HIV transcription through complex interactions with RNA and host cell factors. Tat undergoes multiple posttranslational modifications that regulate the dynamics and complexity of these interactions. The biology of these modifications and their role in Tat function are reviewed. (c) 2005 Elsevier SAS. All rights reserved.

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收藏

页码：1364 / 1369

页数：6

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