Cis (1S,3R)-1-(9-adenyl)-3-hydroxycyclopentane inhibits the respiratory burst from polymorphonuclear leukocytes and has in vivo efficacy in an acute and chronic model of inflammation

被引：3

作者：

Borcherding, DR

Butler, BT

Linnik, MD

Mehdi, S

Dudley, MW

Edwards, CK

机构：

[1] Marion Merrell Dow Res. Institute, Cincinnati, OH 45215-6300

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 05期

关键词：

D O I：

10.1080/07328319608002028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The adenine-containing carbocyclic nucleosides (1) under bar and (2) under bar were synthesized in optically active form and have been shown to effectively inhibit interferon-gamma priming of Lewis (LEW/N) rat air pouch-derived PMNs. Compound (2) under bar was also shown to have in vivo activity in a LEW/N rat antigen-induced arthritis model which assesses acute and chronic inflammation.

引用

页码：967 / 979

页数：13

共 39 条

[1] THE CELL BIOLOGY OF MACROPHAGE ACTIVATION [J].