Abnormal 5-HT1D receptor function in major depression:: A neuropharmacological challenge study using sumatriptan

被引:26
作者
Cleare, AJ
Murray, RM
Sherwood, RA
O'Keane, V
机构
[1] Inst Psychiat, Dept Psychol Med, London SE5 8AF, England
[2] Kings Coll London, Sch Med & Dent, Dept Clin Biochem, London, England
[3] Addenbrookes NHS Trust, Cambridge CB2 2QQ, England
关键词
D O I
10.1017/S003329179700634X
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Background. Sumatriptan, a specific agonist at 5-HT1D receptors, stimulates release of growth hormone (GH) and inhibits release of prolactin (PRL). Methods. We gave sumatriptan (6 mg subcutaneously) to 11 patients with unipolar major depression and 11 control subjects matched for age, sex, weight and menstrual cycle phase. Serum GH and PRL were measured at 0, 15, 30, 45, 60 and 90 min after injection. Results. The maximal rise in GH was significantly reduced in the depressed patients, with 60% showing no increase over baseline compared with 18% of controls. There were no significant differences in PRL responses. Conclusions. These results suggest reduced sensitivity of 5-HT1D receptors in major depression. Our results and those of studies investigating 5-HT1A receptors imply that both 5-HT1A and 5-HT1D autoreceptors may show reduced function in major depression.
引用
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页码:295 / 300
页数:6
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