Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix

被引：77

作者：

Cappello, F ^{[1
]}

Bellafiore, M ^{[1
]}

David, S ^{[1
]}

Anzalone, R ^{[1
]}

Zummo, G ^{[1
]}

机构：

[1] Univ Palermo, Dept Expt Med, I-90136 Palermo, Italy

来源：

CANCER LETTERS | 2003年 / 196卷 / 01期

关键词：

heat shock proteins; carcinogenesis; dysplasia; carcinoma;

D O I：

10.1016/S0304-3835(03)00212-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the present study, we evaluated the presence and the level of expression of HSP10 in two carcinogenetic models: the 'adenoma-carcinoma sequence' of large bowel and the 'dysplasia-carcinoma sequence' of uterine exocervix. We found HSP10 was overexpressed during the carcinogenesis of both organs. In particular, HSP10 was overexpressed early in large bowel carcinogenesis, while the expression of this protein in exocervical carcinogenesis gradually increased from normal through dysplastic to neoplastic tissues. The quantitative analysis of immunohistochemistry and the Western blotting confirmed these results. Our previous observations showed overexpression of HSP60 in the same carcinogenetic models. This report correlates the overexpression of HSP10 with that of HSP60 during carcinogenesis in vivo. These results could stimulate further studies on the pathogenetic role of these proteins during the carcinogenesis as well as their use as diagnostic and prognostic tools in oncology. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：35 / 41

页数：7

共 34 条

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