Synthesis and antifungal activities of novel 1,3-β-D-glucan synthase inhibitors.: Part 1

被引：20

作者：

Masubuchi, K

Okada, T

Kohchi, M

Sakaitani, M

Mizuguchi, E

Shirai, H

Aoki, M

Watanabe, T

Kondoh, O

Yamazaki, T

Satoh, Y

Kobayashi, K

Inoue, T

Horii, I

Shimma, N

机构：

[1] Nippon Roche Res Ctr, Dept Chem, Kamakura, Kanagawa 2478530, Japan

[2] Nippon Roche Res Ctr, Dept Mycol, Kamakura, Kanagawa 2478530, Japan

[3] Nippon Roche Res Ctr, Dept Preclin Sci, Kamakura, Kanagawa 2478530, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00678-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Highly potent 1,3-beta -D-glucan synthase inhibitors 10, 11 and 13 have been identified by the chemical modification of the fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：395 / 398

页数：4

共 10 条

[1] Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis [J].