Synthesis and transfecting properties of a glycosylated polycationic DNA vector

被引：11

作者：

Jacopin, C

Hofland, H

Scherman, D

Herscovici, J

机构：

[1] Ecole Natl Super Chim Paris, UMR 7001 CNRS, LCBBMC, F-75231 Paris, France

[2] Aventis Gencell, Hayward, CA 94545 USA

[3] Aventis Gencell CRVA, Vitry Sur Seine, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(00)00683-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：419 / 422

页数：4

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