Perspectives on skeletal muscle stem cells

被引：247

作者：

Relaix, F. ^{[1
,2
,3
,4
]}

Bencze, M. ^{[1
]}

Borok, M. J. ^{[1
]}

Vartanian, A. Der ^{[1
]}

Gattazzo, F. ^{[1
,3
]}

Mademtzoglou, D. ^{[1
]}

Perez-Diaz, S. ^{[1
]}

Prola, A. ^{[1
,2
]}

Reyes-Fernandez, P. C. ^{[1
]}

Rotini, A. ^{[1
]}

Taglietti, V ^{[1
]}

机构：

[1] Univ Paris Est Creteil, INSERM, IMRB, F-94010 Creteil, France

[2] IMRB, EnvA, F-94700 Maisons Alfort, France

[3] EFS, IMRB, F-94010 Creteil, France

[4] Hop Mondor, AP HP, Serv Histol, F-94010 Creteil, France

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

关键词：

SATELLITE CELLS; SELF-RENEWAL; MAINTAIN QUIESCENCE; ACTIVATION; NICHE; MAINTENANCE; MYOGENESIS; REVEALS; REGENERATION; TRANSITION;

D O I：

10.1038/s41467-020-20760-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and G(alert) states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine. Skeletal muscle has a remarkable regenerative capacity, which can largely be attributed to resident muscle stem cells (MuSCs). Here, the authors review the molecular mechanisms regulating MuSC quiescence, activation and proliferation, how these processes are regulated by the stem cell niche, and the role of MuSCs in neuromuscular diseases.

引用

页数：11

共 104 条

[1]

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis [J].