Potential role of gonadotrophin-releasing hormone (GnRH)-I and GnRH-II in the ovary and ovarian cancer

被引：69

作者：

Kang, SK

Choi, KC

Yang, HS

Leung, PCK

机构：

[1] Univ British Columbia, Dept Obstet & Gynaecol, Vancouver, BC V6H 3V5, Canada

[2] Seoul Natl Univ, Coll Vet Med, Dept Theriogenol & Biotechnol, Seoul, South Korea

[3] Dongguk Univ, Coll Med, Dept Obstet & Gynaecol, Kyongju, South Korea

来源：

ENDOCRINE-RELATED CANCER | 2003年 / 10卷 / 02期

关键词：

D O I：

10.1677/erc.0.0100169

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gonadotrophin-releasing hormone (GnRH) functions as a key neuroendocrine regulator of the hypothalamic-pituitary-gonadal axis. In addition to the hypothalamus and pituitary gland, GnRH and its receptor have been detected in other reproductive tissues including the gonads, placenta and tumours arising from these tissues. Recently, a second form of GnRH (GnRH-II) and type II GnRH receptor have been found in normal ovarian surface epithelium and neoplastic counterparts. The two types of GnRH may play an important role as an autocrine/paracrine regulator of reproductive functions and ovarian tumour growth. In this review, the distribution and potential roles of GnRH-I/-II and their GnRH receptors in the ovarian cells and ovarian cancer will be discussed.

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页码：169 / 177

页数：9

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