Novel approaches to the treatment of osteoporosis

被引：27

作者：

Appelman-Dijkstra, Natasha M. ^{[1
]}

Papapoulos, Socrates E. ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Ctr Bone Qual, NL-2333 ZA Leiden, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2014年 / 28卷 / 06期

关键词：

bone formation; bone resorption; osteoporosis; cathepsin K; PTHrP; sclerostin; BONE-MINERAL DENSITY; CATHEPSIN-K INHIBITOR; PARATHYROID-HORMONE; 1-34; VAN-BUCHEM-DISEASE; POSTMENOPAUSAL WOMEN; SCLEROSTIN ANTIBODY; BIOCHEMICAL MARKERS; VERTEBRAL FRACTURE; SOST GENE; ODANACATIB;

D O I：

10.1016/j.beem.2014.07.003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Despite the availability of efficacious treatments for fracture reduction in patients with osteoporosis, there are still unmet needs requiring a broader range of therapeutics. In particular, agents that are capable of replacing already lost bone and that also drastically reduce the risk of non-vertebral fractures are needed. Studies of rare bone diseases in humans and animal genetics have identified targets in bone cells for the development of therapies for osteoporosis with novel mechanisms of action. Here, we review these new developments, with emphasis on inhibitors of cathepsin K in osteoclasts and sclerostin in osteocytes, which are currently studied in phase 3 clinical trials. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：843 / 857

页数：15

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