Catalytic enantioselective fluorination and amination of β-keto phosphonates catalyzed by chiral palladium complexes

被引：163

作者：

Kim, SM ^{[1
]}

Kim, HR ^{[1
]}

Kim, DY ^{[1
]}

机构：

[1] Soonchunhyang Univ, Div Appl Sci, Dept Chem, Asan 336745, Chungnam, South Korea

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 12期

关键词：

D O I：

10.1021/ol050413a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The catalytic enantioselective fluorination and amination of beta-keto phosphonates catalyzed by chiral palladium complexes is described. Treatment of beta-keto phosphonates with N-fluorobenzenesulfonimide (NFSI) as electrophilic fluorinating reagent and diethyl azodicarboxylate (DEAD) as electrophilic amination reagent under mild reaction conditions afforded the corresponding alpha-substituted beta-keto phosphonates in moderate to excellent yields with excellent enantiomeric excesses.

引用

页码：2309 / 2311

页数：3

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