Human mesenchymal stem cells: from basic biology to clinical applications

被引：301

作者：

Abdallah, B. M.

Kassem, M. ^{[1
]}

机构：

[1] Odense Univ Hosp, Dept Endocrinol, KMEB, DK-5000 Odense C, Denmark

来源：

GENE THERAPY | 2008年 / 15卷 / 02期

关键词：

hMSC; stem cell; clinical applications; cell therapy;

D O I：

10.1038/sj.gt.3303067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Mesenchymal stem cells (MSC) are a group of clonogenic cells present among the bone marrow stroma and capable of multilineage differentiation into mesoderm-type cells such as osteoblasts, adipocytes and chondrocytes. Due to their ease of isolation and their differentiation potential, MSC are being introduced into clinical medicine in variety of applications and through different ways of administration. Here, we discuss approaches for isolation, characterization and directing differentiation of human mesenchymal stem cells (hMSC). An update of the current clinical use of the cells is also provided.

引用

收藏

页码：109 / 116

页数：8

相关论文

共 92 条

[1]

Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1 [J].

Abdallah, BM ;

Jensen, CH ;

Gutierrez, G ;

Leslie, RGQ ;

Jensen, TG ;

Kassem, M .

JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (05) :841-852

[2]

Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene in despite of extensive proliferation [J].

Abdallah, BM ;

Haack-Sorensen, M ;

Burns, JS ;

Elsnab, B ;

Jakob, F ;

Hokland, P ;

Kassem, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 326 (03) :527-538

[3]

LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors [J].

Allay, JA ;

Dennis, JE ;

Haynesworth, SE ;

Majumdar, MK ;

Clapp, DW ;

Shultz, LD ;

Caplan, AI ;

Gerson, SL .

HUMAN GENE THERAPY, 1997, 8 (12) :1417-1427

[4]

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI) [J].

Assmus, B ;

Schächinger, V ;

Teupe, C ;

Britten, M ;

Lehmann, R ;

Döbert, N ;

Grünwald, F ;

Aicher, A ;

Urbich, C ;

Martin, H ;

Hoelzer, D ;

Dimmeler, S ;

Zeiher, AM .

CIRCULATION, 2002, 106 (24) :3009-3017

[5]

Treatment of chronic wounds with bone marrow-derived cells [J].

Badiavas, EV ;

Falanga, V .

ARCHIVES OF DERMATOLOGY, 2003, 139 (04) :510-516

[6]

Tissue distribution and engraftment of human mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene [J].

Bentzon, JF ;

Stenderup, K ;

Hansen, FD ;

Schroder, HD ;

Abdallah, BM ;

Jensen, TG ;

Kassem, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 330 (03) :633-640

[7]

Ex vivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2 [J].

Bianchi, G ;

Banfi, A ;

Mastrogiacomo, M ;

Notaro, R ;

Luzzatto, L ;

Cancedda, R ;

Quarto, R .

EXPERIMENTAL CELL RESEARCH, 2003, 287 (01) :98-105

[8]

Bone marrow stromal stem cells: Nature, biology, and potential applications [J].

Bianco, P ;

Riminucci, M ;

Gronthos, S ;

Robey, PG .

STEM CELLS, 2001, 19 (03) :180-192

[9]

Stem cells in tissue engineering [J].

Bianco, P ;

Robey, PG .

NATURE, 2001, 414 (6859) :118-121

[10]

MESENCHYMAL STEM-CELLS IN IN BONE-DEVELOPMENT, BONE REPAIR, AND SKELETAL REGENERATION THERAPY [J].

BRUDER, SP ;

FINK, DJ ;

CAPLAN, AI .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, 56 (03) :283-294

← 1 2 3 4 5 6 7 8 9 10 →