High-mobility group box 1 (HMGB1) as a master regulator of innate immunity

被引：91

作者：

Castiglioni, Alessandra ^{[1
,2
]}

Canti, Valentina ^{[1
,2
]}

Rovere-Querini, Patrizia ^{[1
,2
]}

Manfredi, Angelo A. ^{[1
,2
]}

机构：

[1] Ist Sci San Raffaele, Div Regenerat Med Stem Cells & Gene Therapy, I-20132 Milan, Italy

[2] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

来源：

CELL AND TISSUE RESEARCH | 2011年 / 343卷 / 01期

关键词：

High-mobility group box 1 (HMGB1); Innate immunity; Damage-associated molecular patterns (DAMPs); SYSTEMIC-LUPUS-ERYTHEMATOSUS; CHROMATIN PROTEIN HMGB1; MOLECULAR-PATTERN MOLECULES; MATURING DENDRITIC CELLS; GLYCATION END-PRODUCTS; INFLAMMATORY RESPONSES; NECROTIC CELLS; TISSUE-DAMAGE; DYING CELLS; ANTICANCER CHEMOTHERAPY;

D O I：

10.1007/s00441-010-1033-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Damage-associated molecular patterns (DAMPs) comprise intracellular molecules characterized by the ability to reach the extracellular environment, where they prompt inflammation and tissue repair. The high-mobility box group 1 (HMGB1) protein is a prototypic DAMP and is highly conserved in evolution. HMGB1 is released upon cell and tissue necrosis and is actively produced by immune cells. Evidence suggests that HMGB1 acts as a key molecule of innate immunity, downstream of persistent tissue injury, orchestrating inflammation, stem cell recruitment/activation, and eventual tissue remodeling.

引用

页码：189 / 199

页数：11

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