Cell-Based Therapies for Diabetic Complications

被引：40

作者：

Bernardi, Stella ^{[1
,2
,3
]}

Severini, Giovanni Maria ^{[4
]}

Zauli, Giorgio ^{[4
]}

Secchiero, Paola ^{[1
,2
]}

机构：

[1] Univ Ferrara, Dept Morphol & Embriol, I-44100 Ferrara, Italy

[2] Univ Ferrara, LTTA Ctr, I-44100 Ferrara, Italy

[3] Baker IDI Heart & Diabet Inst, Melbourne, Vic 3004, Australia

[4] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, I-34137 Trieste, Italy

来源：

EXPERIMENTAL DIABETES RESEARCH | 2012年

关键词：

ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL STEM-CELLS; MULTIPOTENT STROMAL CELLS; ANGIOGENIC GROWTH-FACTORS; ACTIVATED PROTEIN-KINASE; BLOOD-FLOW RESTORATION; MYOCARDIAL-INFARCTION; HEART-FAILURE; HIGH-GLUCOSE; IN-VITRO;

D O I：

10.1155/2012/872504

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years, accumulating experimental evidence supports the notion that diabetic patients may greatly benefit from cell-based therapies, which include the use of adult stem and/or progenitor cells. In particular, mesenchymal stem cells and the circulating pool of endothelial progenitor cells have so far been the most studied populations of cells proposed for the treatment of vascular complications affecting diabetic patients. We review the evidence supporting their use in this setting, the therapeutic benefits that these cells have shown so far as well as the challenges that cell-based therapies in diabetic complications put out.

引用

页数：10

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