Leptin activates hypothalamic CART neurons projecting to the spinal cord

被引：617

作者：

Elias, CF

Lee, C

Kelly, J

Aschkenasi, C

Ahima, RS

Couceyro, PR

Kuhar, MJ

Saper, CB

Elmquist, JK ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurol, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Neurol, Program Neurosci, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Dept Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[4] Harvard Univ, Sch Med, Div Endocrinol, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[5] Emory Univ, Yerkes Reg Primate Res Ctr, Atlanta, GA 30329 USA

来源：

NEURON | 1998年 / 21卷 / 06期

关键词：

D O I：

10.1016/S0896-6273(00)80656-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The adipocyte-derived hormone leptin decreases body weight in part by activating the sympathetic nervous system, resulting in increased thermogenesis and energy expenditure. We investigated hypothalamic pathways underlying leptin's effects on stimulating the sympathetic nervous system. We found that leptin activates neurons in the retrochiasmatic area (RCA) and lateral arcuate nucleus (Arc) that innervate the thoracic spinal cord and also contain cocaine- and amphetamine-regulated transcript (CART). We also found that most CART-containing neurons in the RCA and Are of the hypothalamus also contain proopiomelanocortin (POMC) mRNA. The finding that leptin activates CART/POMC neurons innervating sympathetic preganglionic neurons in the thoracic spinal cord suggests that this pathway may contribute to the increased thermogenesis and energy expenditure and decreased body weight observed following leptin administration.

引用

页码：1375 / 1385

页数：11

共 80 条

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