Preparation and evaluation of ketoconazole-beta-cyclodextrin multicomponent complexes

被引：60

作者：

EsclusaDiaz, MT ^{[1
]}

GayoOtero, M ^{[1
]}

PerezMarcos, MB ^{[1
]}

VilaJato, JL ^{[1
]}

TorresLabandeira, JJ ^{[1
]}

机构：

[1] UNIV SANTIAGO DE COMPOSTELA,SCH PHARM,PHARMACEUT TECHNOL LAB,SANTIAGO COMPOSTE 15706,SPAIN

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 142卷 / 02期

关键词：

ketoconazole; beta-cyclodextrin complexes; dissolution properties; multicomponent systems; solubility;

D O I：

10.1016/0378-5173(96)04666-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Increase in poor buffer pH 5 and 6 solubility of ketoconazole was studied. Two systems were used: binary complexes prepared with beta-cyclodextrin and multicomponent systems (beta-cyclodextrin and an acid compound), obtained by spray-drying. X-ray diffractometry and differential scanning calorimetry showed differences between ketoconazole/cyclodextrin complexes and their corresponding physical mixtures and individual components. The solubility of ketoconazole increased significantly with the cyclodextrin complexes. However, enhancement was better from the multicomponent systems.

引用

页码：183 / 187

页数：5

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