Inflammasomes: mechanism of action, role in disease, and therapeutics

被引：2541

作者：

Guo, Haitao ^{[1
]}

Callaway, Justin B. ^{[1
]}

Ting, Jenny P-Y ^{[1
,2
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Genet, Chapel Hill, NC USA

来源：

NATURE MEDICINE | 2015年 / 21卷 / 07期

基金：

美国国家卫生研究院;

关键词：

PATTERN-RECOGNITION RECEPTORS; GAMMA-INDUCING FACTOR; NLRP3; INFLAMMASOME; ADIPOSE-TISSUE; INSULIN-RESISTANCE; NALP3; BACTERIAL LIGANDS; AIM2; ADAPTER ASC; FATTY-ACIDS;

D O I：

10.1038/nm.3893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. They have been implicated in a host of inflammatory disorders. Recent developments have greatly enhanced our understanding of the molecular mechanisms by which different inflammasomes are activated. Additionally, increasing evidence in mouse models, supported by human data, strongly implicates an involvement of the inflammasome in the initiation or progression of diseases with a high impact on public health, such as metabolic disorders and neurodegenerative diseases. Finally, recent developments pointing toward promising therapeutics that target inflammasome activity in inflammatory diseases have been reported. This review will focus on these three areas of inflammasome research.

引用

页码：677 / 687

页数：11

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